Nuclear Pore Complex Antibodies

Nuclear pore complex antibodies are implicated in scientific discovery focused on the large protein complexes, nucleoporins, that cross the nuclear envelope and permit the transport of water soluble molecules, including RNA and ribosome’s moving outbound from the nucleus and proteins , carbohydrates, lipids etc moving inbound into the cell nucleus.

Nuclear pore complex antibodies research aid understanding in distinct disease area's including Triple A syndrome, myeloid leukaemia and certain tumour formation.

Nuclear pore complex antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.

Research Notes on nuclear pore complex antibodies are available

Lamin A+C Antibody [JOL2]: Horseradish peroxidase

IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon

Product Code:IQ608HRP
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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Lamin A+C Antibody [JOL2]

Product Code:IQ608
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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gp210 Antibody

Product Code:IQ294
Reactivity: Mouse, Rat, Human, Monkey
Application: Immunofluorescence, Western blot
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gp210 Antibody

Immunocytochemistry/ Immunofluorescence - GP210 antibody on formaldehyde fixed HeLa cells

Product Code:IQ244
Reactivity: Human, Rat, Xenopus laevis. Predicted to work with all Mammals
Application: Immunoblot, Western blot
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Mad2 Antibody

MAD2 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators.hMAD2 is the human homologue of yeast MAD2

Product Code:IQ243
Reactivity: Human, Saccharomyces cerevisiae
Application: Immunofluorescence, Western blot
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Ran Antibody

Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Product Code:IQ241
Reactivity: Yeast 
Application: Immunofluorescence, Western blot
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Nup53 Antibody

Nup53 encodes a recently identified nuclear pore protein. Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complex (NPC), a large macromolecular complex that spans the nuclear envelope. The yeast NPC shares several features with the vertebrate NPC, despite being smaller and less elaborate. Nup53p forms a complex with two other nucleoporins, Nup170p and Asm4p. The complex is found on both the nuclear and cytoplasmic faces of the NPC, and associates with Pse1p, a member of a protein family implicated in nuclear protein import, via direct interaction between Nup53p and Pse1p. Nup53p is structurally similar to Asm4p, and similar proteins sequences are found in several eukaryotes including human and other multicellular species. Nup53p is not essential; deletion of Nup53 and ASM4 causes slow growth and altered subcellular distribution of Pse1p. In a nup53 pse1 double mutant, NLS-containing proteins are mislocalized to the cytoplasm

Product Code:IQ240
Reactivity: Human, Rat, Saccharomyces cerevisiae
Application: Immunoblot, Immunofluorescence
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Mad1 Antibody [9B10]

Western blot - Anti-MAD1 antibody [9B10]

Product Code:IQ200
Reactivity: Human 
Application: Immunofluorescence,Immunoprecipitation, Flow cytometry
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Nup153 Antibody

Immunofluorescence showing Nup 153 in HeLa cells

Product Code:IQ178
Reactivity: Human, Rat, Xenopus laevis
Application: Immunoblot, Immunofluorescence, Immunoprecipitation
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