Cytoskeleton Antibodies

Cytoskeleton antibodies are indicated in work understanding the cytoskeleton , the organising infrastructure of the cell, both scaffolding for cellular components and facilitative for intracellular organelle movement and information transmission.

Cytoskeleton antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.

Plakophilin 1 Antibody [19F10]

Western blot showing Anti-Plakophilin 1 [19F10] on HaCat keratinocyte cells

Product Code:IQ576
Reactivity: Mouse, Human
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Ajuba Antibody [21G4]

Western blot showing Anti-Ajuba (21G4) on HaCat keratinocyte cells

Product Code:IQ583
Reactivity: Human 
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SLC9A3R2 Antibody [32B6]

Western blot showing SLC9A3R2 Antibody [32B6] on HaCat keratinocyte cells

Product Code:IQ577
Reactivity: Human. Predicted to work with: Mouse, Rat 
Application: Western blot, Immunoprecipitation
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Podoplanin/gp36 Antibody [8.1.1]

Frozen section of Mouse kidney stained with Hamster Anti-Podoplanin/gp36 [clone 8.1.1]

Product Code:IQ445
Reactivity: Mouse
Application: Immunoblot, Immunohistochemistry (frozen sections), Immunoprecipitation
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Kallikrein 2 Antibody [6B7]

Product Code:IQ334
Reactivity: Human
Application: ELISA, Immunocytochemistry, Immunohistochemistry (frozen sections)
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Kallikrein 2 Antibody [6B7]

Kallikreins (KLKs) are a subgroup of trypsin-like serine proteases and are implicated in carcinogenesis Kallikrein 2 is most closely related to Kallikrein 3 (PSA) with 78 identity and with kallikrein 1 at 68 identity Like Kallikrein 3 Kallikrein 2 is found in greatest abundance in the prostate but at much lower levels than Kallikrein 3 In addition Kallikrein 2 seems to be more labile than Kallikrein 1 or Kallikrein 3 and is often found in a cleaved form Kallikrein 2 is inhibited by Protein C Inhibitor (PCI)

Product Code:IQ333
Reactivity: Human
Application: ELISA, Immunofluorescence, Immunocytochemistry, Immunohistochemistry (paraffin sections)
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Cytokeratin 10-1 Antibody [AE20]

Immunohistochemistry showing Anti-Cytokeratin K10-1 on formalin fixed paraffin embedded skin tissue

Product Code:IQ293
Reactivity: Human 
Application: Immunoblot, Immunohistochemistry (paraffin sections)
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Hair Cortex Cytokeratin Antibody [AE13]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - hair cortex Cytokeratin antibody [AE13] staining mouse skin tissue sections

Product Code:IQ292
Reactivity: Mouse, Human
Application: Immunoblot, Immunohistochemistry (paraffin sections)
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Cytokeratin 13 Antibody [AE8]

Immunohistochemistry of Anti-Cytokeratin 13 [AE8] on formalin fixed paraffin embedded tonsil tissue

Product Code:IQ291
Reactivity: Mouse, Rabbit, Human
Application: Immunoblot, Immunohistochemistry (paraffin sections)
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Cytokeratin 3 [AE5] Antibody

Immunocytochemistry/ Immunofluorescence - Anti-Cytokeratin 3 antibody [AE5] staining Cytokeratin 3 (red) in transfected Ptk2 cells

Product Code:IQ290
Reactivity: Rabbit, Cow, Human
Application: Immunoblot, Immunohistochemistry (paraffin sections)
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Cytokeratin AE1 Antibody [CK 210 (AE1)]

Human kidney (parafin embedded) stained with Cytokeratin type I (AE1)

Product Code:IQ288
Reactivity: Mouse, Rat, Rabbit, Chicken, Cow, Human, Pig, Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections)
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Mad2 Antibody

MAD2 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators.hMAD2 is the human homologue of yeast MAD2

Product Code:IQ243
Reactivity: Human, Saccharomyces cerevisiae
Application: Immunofluorescence, Western blot
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Mad1 Antibody

MAD1 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated upon spindle depolymerization

Product Code:IQ242
Reactivity: Saccharomyces cerevisiae
Application: Immunofluorescence, Western blot
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NEK2 Antibody

NEK2 is closely related in its catalytic domain to the serine/threonineprotein kinase NIMA of Aspergillus nidulans which is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2. These observations demonstrate that NEK2 resembles Aspergillus NIMA, both in its catalytic domain, and cell cycle-dependent expression. Recombinant NEK2 is active as a serine/threonine-specific protein kinase and may undergo autophosphorylation. Both human NEK2 and fungal NIMA phosphorylate a similar, but not identical, set of proteins and synthetic peptides. NEK2 is shown to be expressed most abundantly in adult testis and there is increasing evidence that NEK2 is abnormally expressed in a wide variety of human cancers

Product Code:IQ231
Reactivity: Recognises both splice variants of human NEK2 (NEK2A and NEK2B)
Application: Western blot
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