The KJ1-26 anti-idiotypic monoclonal antibody binds the T-cell receptor (TCR) expressed on DO11.10 and DO11.10.24 murine T cell hybridomas, but not on any other T cell hybridomas tested.The TCR expressed on DO11.10 recognizes an ovalbumin peptide in the context of I-Ad major histocompatibility molecules.The use of DO11.10 and KJ1-26 have proven to be instrumental in describing many of the intricate details of T cell immunity

The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits alpha and beta of similar molecular weight 40 to 55 kD in the human Like the immunoglobulins of the B cells each T cell receptor subunit has external to the cell membrane an N terminal variable domain and a C terminal constant domain T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain In a single cell the T cell receptor loci are rearranged and expressed in the order delta gamma beta and alpha If both delta and gamma rearrangements produce functional chains the cell expresses delta and gamma If not the cell proceeds to rearrange the beta and alpha loci