Cell Signalling Antibodies

This range of Immuquest cell cycle/signalling/transcription antibodies supports a board range of cell cycle, replication and protein transport mechanisms.

These cell cycle/signalling/transcription antibodies are implicated in a broad range of disease areas including cancer therapy.

Cell cycle /signalling/transcription factor antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.

FANCD2 (pSer717) [P-CS-5]

Western blot analysis of U87 cells either treated (RH) or untreated with temezolamide prior to analysis of total lysate either with indicated phospho-specific antibody or anti-FANCD2 antibody [P-CS-5] by immunoblotting blotting

Product Code:IQ655
Reactivity: Human
Application: ELISA,Western blot
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BRCA2 (pSer3291) [P-CS-4]

Western blot analysis of Hela cells either treated (LH) or untreated with nocodazole prior to analysis of total lysate either with indicated phospho-specific antibody or anti-BRCA2 antibody [P-CS-4] by immunoblotting blotting

Product Code:IQ654
Reactivity: Human
Application: ELISA, Immunoblot, Western blot
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Upf1/Rent1 (pThr28) Antibody [P-CS-1]

Western blot analysis of wild-type and phospho-site mutant Flag-tagged Upf1 (P-CS-1) isogenically expressed in Hela cells and immuno-precipitated with anti-Flag antibody prior to blotting

Product Code:IQ653
Reactivity: Human
Application: ELISA, Immunoblot, Western blot
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Lamin A+C Antibody [JOL2]: Horseradish peroxidase

IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon

Product Code:IQ608HRP
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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Desmoglein 2 Antibody [10D2]

Western blot showing Anti-Desmoglein 2 (10D2) on HaCat keratinocyte cells

Product Code:IQ579
Reactivity: Human Predicted to work with: Mouse
Application: Immunoblot, Immunofluorescence, Immunoprecipitation
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hCAP-D3 Antibody [2B5]

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4. hCAP-D3 is a regulatory non-SMC subunit of the condensin II complex

Product Code:IQ554
Reactivity: Human 
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HDAC3 Antibody [3G6]

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation

Product Code:IQ553
Reactivity: Human, Mouse 
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HDAC1 Antibody [10E2]

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity

Product Code:IQ555
Reactivity: Mouse, Rat, Human
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FNIP1 Antibody

Birt-Hogg-Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(FLCN) gene, which encodes a tumor-suppressor protein, folliculin (FLCN), with unknown function. The tumor-suppressor proteins encoded by genes responsible for several other hamartoma syndromes, LKB1, TSC1/2, and PTEN, have been shown to be involved in the mammalian target of rapamycin (mTOR) signaling pathway

Product Code:IQ351
Reactivity: Mouse, Human
Application: Immunoblot, Immunoprecipitation
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Kallikrein 2 Antibody [6B7]

Product Code:IQ334
Reactivity: Human
Application: ELISA,Immunocytochemistry,Immunohistochemistry (frozen sections)
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Emerin Antibody

Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution

Product Code:IQ323
Reactivity: Mouse, Rat, Hamster, Human
Application: Immunoblot, Immunofluorescence
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HEF-1 Antibody [14A11]

Product Code:IQ299
Reactivity: Human
Application: Immunofluorescence,Immunoprecipitation
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HEF-1 Antibody [14A11]

HEF1 is a multifunctional protein involved in integrin-based signaling that affects cell motility growth apoptosis and oncogenic transformation The Cas family of docking proteins have been the subject of intense research because of their role in cell motility growth apoptosis and oncogenic transformation These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility cell transformation and invasiveness including several metalloproteinases MLCK p160ROCK and ErbBi HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines including MCF7 and HeLa cells Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas) a related protein is associated with tamoxifen resistance This highlights the importance of studying the role of this family of proteins in cancer prognosis

Product Code:IQ298
Reactivity: Human
Application: Immunofluorescence, Immunoprecipitation
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Aurora B Antibody

Immunohistochemistry of Aurora B antibody on formalin fixed paraffin embedded skin tissue

Product Code:IQ234
Reactivity: Human 
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot
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