Lamin A+C Antibody [JOL2]: Horseradish peroxidase

IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon

Product Code:IQ608HRP
Reactivity: Human, African Green Monkey
Application: Immunoblot,Immunohistochemistry (paraffin sections),Western blot,Immunoprecipitation
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Lamin A+C Antibody [JOL2]

Product Code:IQ608
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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GBV-C virus glycoprotein E2 Antibody [UIE2-1]

Product Code:IQ584
Application: ELISA,Western blot
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Beta 2 microglobulin Antibody [C21]

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system

Product Code:IQ424
Reactivity: Human
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Hepatitis B virus core antigen [10E11] Antibody

Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection

Product Code:IQ571
Reactivity: Recognizes woodchuck hepatitis B Virus (WHV) core protein, but not Duck Hepatitis B Virus (DHBV) core protein
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Hepatitis B virus core antigen Antibody [14E11]

Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection

Product Code:IQ570
Reactivity: Recognizes woodchuck hepatitis B Virus (WHV) core protein, but not Duck Hepatitis B Virus (DHBV) core protein
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Desmoglein 2 Antibody [7H9]

Western blot using Desmoglein 2 antibody [7H9] on A431 cell lysate

Product Code:IQ580
Reactivity: Human 
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EAPP Antibody [1E4]

Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis

Product Code:IQ545
Reactivity: Human, Mouse
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Apolipoprotein E4 Antibody [4E4]

Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents.ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer's disease. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased levels of plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants

Product Code:IQ552
Reactivity: Human
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Lamin A+C mutant R482W Antibody [5H8-B4]

Lamins and lamin-associated proteins help cell nuclear shape to remain appropriate and also provide a scaffold-type support system for chromosomes and replicating DNA to interact with epigenetic machinery. When mutations to these important proteins occur, serious familial diseases are instigated. The R482W lamin mutation causes familial partial lipodystrophy (FPLD) phenotypes, a disorder that causes affected individuals to be incapable of normal fat distribution, to have insulin resistance, dyslipidemia and early cardiac heart disease. The mutation affects the lamin C-terminal domain's ability to bind DNA, and is typically thought to be attributed to oxidative stress. Women affected by FPLD are even more afflicted, in that they are at a higher risk of infertility, gestational diabetes, obstectrical complications, insulin regulation dysfunctions, and hypercholesterolemia

Product Code:IQ546
Reactivity: Human
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Lamin A+C mutant R453W Antibody [12A-2F5]

Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamin A and Lamin C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R453W mutation is one of the most common causes of autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD)

Product Code:IQ541
Reactivity: Human
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Lipoprotein Lipase Antibody [5D2]

Permeabilised Mouse cortical glia stained with anti-LPL [5D2] (green) and Hoechst (blue)

Product Code:IQ449
Reactivity: Human, Mouse, Rat, Syrian Hamster, Cat
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Progerin Antibody [13A4D4]

Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin A and C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acids internal deletion within the carboxyl-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of LMNA gene

Product Code:IQ557
Reactivity: Human
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Clostridium botulinus toxin A

Clostridium botulinum neurotoxins are zinc-dependent proteases that block the release of acetylcholine from peripheral cholinergic nerve endings by targeting specific membrane proteins including synaptosomal-associated proteins (SNAP), vesicle-associated membrane proteins (VAMP), and syntaxins. Neurotoxin A is characteristically associated with human botulism and known to target and hydrolyse the 197-Gln-|-Arg-198 bond of SNAP-25

Product Code:IQ540
Application: ELISA
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CA19-9 Antibody [121SLE]

FFPE Human Colon stained with Ca19.9 Sialyl Lewis a, clone 121SLE at 2ug/ml

Product Code:IQ422
Reactivity: Human
Application: Immunohistochemistry (paraffin sections)
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NOX2/gp91phox Antibody [54.1]

Western blot analysis of NOX2/gp91phox, 54.1 expression in A-431

Product Code:IQ439
Reactivity: Human
Application: Western blot
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NOX2/gp91phox Antibody [NL7]

Western blot showing Mouse Anti-gp91phox, clone NL7

Product Code:IQ438
Reactivity: Human 
Application: Western blot
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NOX2/gp91phox Antibody [CL5]

Western blot showing Mouse Anti-gp91phox, clone CL5

Product Code:IQ437
Reactivity: Human 
Application: Western blot
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