Nuclear Envelope Antibodies

Nuclear envelope antibodies relate to the nuclear envelope which is a thin membrane that surrounds the genetic material in eukaryotic cells. It consists of a double layer of lipids, separating the nucleus content, principally DNA, from the surrounding cell cytoplasm.

The outer part of the nuclear envelope membrane is rough endoplasmic reticulum spotted as it is with ribosomes. The inner part consists of flat membrane proteins e.g. Emerin which are linked to the nuclear lamina and mutations in Lamins A and B

These mutations are thought to be linked to laminopathic diseases like Emery Dreifuss muscular dystrophy, limb-girdle muscular dystrophy type 1B, dilated cardiomyopathy with conduction defect, and Charcot-Marie-Tooth disorder type 2B1 which the use of nuclear envelope antibodies reach is indicated

The nuclear envelope is perforated with pores which enable the transport of proteins and RNA between the nucleus and cytoplasm. The inner and outer membrane conjoin at each nuclear pore site.

Nuclear envelope antibodies are available in various quantities including 0.05 ml, 0.1ml, 0.2 ml ,1 ml.