Nuclear Envelope Antibodies

Nuclear envelope antibodies relate to the nuclear envelope which is a thin membrane that surrounds the genetic material in eukaryotic cells. It consists of a double layer of lipids, separating the nucleus content, principally DNA, from the surrounding cell cytoplasm.

The outer part of the nuclear envelope membrane is rough endoplasmic reticulum spotted as it is with ribosomes. The inner part consists of flat membrane proteins e.g. Emerin which are linked to the nuclear lamina and mutations in Lamins A and B

These mutations are thought to be linked to laminopathic diseases like Emery Dreifuss muscular dystrophy, limb-girdle muscular dystrophy type 1B, dilated cardiomyopathy with conduction defect, and Charcot-Marie-Tooth disorder type 2B1 which the use of nuclear envelope antibodies reach is indicated

The nuclear envelope is perforated with pores which enable the transport of proteins and RNA between the nucleus and cytoplasm. The inner and outer membrane conjoin at each nuclear pore site.

Nuclear envelope antibodies are available in various quantities including 0.05 ml, 0.1ml, 0.2 ml ,1 ml.

Lamin A/C antibody [JOL3]: FITC

Confocal optical section, green is FITC (lamin A/C [JOL3]) and blue is DAPI (DNA). Cells were fixed in 4% paraformaldehyde in PEM buffer then extracted with 0.5% Triton X-100 before labelling with JOL3-FITC.

Product Code:IQ656FITC
Reactivity: Human, Mouse, Rat
Application: Immunofluorescence, Immunocytochemistry
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Lamin A+C Antibody [JOL2]: Horseradish peroxidase

IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon

Product Code:IQ608HRP
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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Lamin A+C Antibody [JOL2]

Product Code:IQ608
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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Nesprin 2 Antibody [K20-478-5]

Immunofluorescence staining of paraformaldehyde fixed HaCaT cells using clone K20-478-5

Product Code:IQ562
Reactivity: Human 
Application: Immunoblot, Immunocytochemistry, Immunoprecipitation
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SUN2 Antibody

Product Code:IQ563
Reactivity: Human 
Application: Immunoblot, Immunofluorescence, Western blot, Immunoprecipitation
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Nesprin 2 Antibody

* Not Available to Resellers

Product Code:IQ565
Reactivity: Mouse 
Application: Immunoblot, Immunofluorescence, Western blot, Immunoprecipitation
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Nesprin 3 Antibody

* Not available to Resellers

Product Code:IQ566
Reactivity: Mouse 
Application: Immunoblot, Immunofluorescence, Western blot, Immunoprecipitation
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Lamin A+C mutant R453W Antibody [12A-2F5]

Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamin A and Lamin C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R453W mutation is one of the most common causes of autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD)

Product Code:IQ541
Reactivity: Human
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SUN2 Antibody

Immunofluorescence showing SUN2 Antibody [IQ444] on NIH 3T3 cells fixed with PFA

Product Code:IQ444
Reactivity: Mouse 
Application: Immunoblot, Immunofluorescence
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Lamin A+C Antibody [JOL2]

Product Code:IQ332
Reactivity: Human, African Green Monkey
Application: Immunohistochemistry (paraffin sections), Western blot, Flow cytometry, Immunoprecipitation
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Lamin A Antibody [JOL4]

Product Code:IQ330
Reactivity: Human, Mouse
Application: Immunofluorescence, Immunohistochemistry (frozen sections), Western blot, Immunoprecipitation
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Lamin A Antibody [JOL4]

Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]

Product Code:IQ329
Reactivity: Human, Mouse
Application: Immunofluorescence, Immunohistochemistry (frozen sections), Western blot, Immunoprecipitation
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Emerin Antibody

Product Code:IQ324
Reactivity: Mouse, Rat, Hamster
Application: Immunoblot, Immunofluorescence
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Emerin Antibody

Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution

Product Code:IQ323
Reactivity: Mouse, Rat, Hamster, Human
Application: Immunoblot, Immunofluorescence
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TAP1 Antibody [53H8]

Product Code:IQ279
Reactivity: Human 
Application: ELISA,Immunofluorescence,Western blot,Immunoprecipitation
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Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Code:IQ252
Reactivity: Mouse, Human
Application: Immunofluorescence, Western blot
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Lamin A+C Antibody [JoL3] - Nuclear Envelope Marker

Immunocytochemistry/ Immunofluorescence - Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Product Code:IQ251
Reactivity: Mouse, Rat, Human
Application: Immunofluorescence, Western blot
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Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Code:IQ188
Reactivity: Mouse, Human
Application: Immunofluorescence, Western blot
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