Nuclear envelope antibodies relate to the nuclear envelope which is a thin membrane that surrounds the genetic material in eukaryotic cells. It consists of a double layer of lipids, separating the nucleus content, principally DNA, from the surrounding cell cytoplasm.
The outer part of the nuclear envelope membrane is rough endoplasmic reticulum spotted as it is with ribosomes. The inner part consists of flat membrane proteins e.g. Emerin which are linked to the nuclear lamina and mutations in Lamins A and B
These mutations are thought to be linked to laminopathic diseases like Emery Dreifuss muscular dystrophy, limb-girdle muscular dystrophy type 1B, dilated cardiomyopathy with conduction defect, and Charcot-Marie-Tooth disorder type 2B1 which the use of nuclear envelope antibodies reach is indicated
The nuclear envelope is perforated with pores which enable the transport of proteins and RNA between the nucleus and cytoplasm. The inner and outer membrane conjoin at each nuclear pore site.
Nuclear envelope antibodies are available in various quantities including 0.05 ml, 0.1ml, 0.2 ml ,1 ml.
Lamin A/C antibody [JOL3]: FITC
Confocal optical section, green is FITC (lamin A/C [JOL3]) and blue is DAPI (DNA). Cells were fixed in 4% paraformaldehyde in PEM buffer then extracted with 0.5% Triton X-100 before labelling with JOL3-FITC.
| Product Code: | IQ656FITC |
| Reactivity: | Human, Mouse, Rat |
| Application: | Immunofluorescence, Immunocytochemistry |
Lamin A+C Antibody [JOL2]: Horseradish peroxidase
IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon
| Product Code: | IQ608HRP |
| Reactivity: | Human, African Green Monkey |
| Application: | Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation |
Lamin A+C Antibody [JOL2]
| Product Code: | IQ608 |
| Reactivity: | Human, African Green Monkey |
| Application: | Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation |
Nesprin 2 Antibody [K20-478-5]
Immunofluorescence staining of paraformaldehyde fixed HaCaT cells using clone K20-478-5
| Product Code: | IQ562 |
| Reactivity: | Human |
| Application: | Immunoblot, Immunocytochemistry, Immunoprecipitation |
SUN2 Antibody
| Product Code: | IQ563 |
| Reactivity: | Human |
| Application: | Immunoblot, Immunofluorescence, Western blot, Immunoprecipitation |
Nesprin 2 Antibody
* Not Available to Resellers
| Product Code: | IQ565 |
| Reactivity: | Mouse |
| Application: | Immunoblot, Immunofluorescence, Western blot, Immunoprecipitation |
Nesprin 3 Antibody
* Not available to Resellers
| Product Code: | IQ566 |
| Reactivity: | Mouse |
| Application: | Immunoblot, Immunofluorescence, Western blot, Immunoprecipitation |
Lamin A+C mutant R453W Antibody [12A-2F5]
Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamin A and Lamin C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R453W mutation is one of the most common causes of autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD)
| Product Code: | IQ541 |
| Reactivity: | Human |
SUN2 Antibody
Immunofluorescence showing SUN2 Antibody [IQ444] on NIH 3T3 cells fixed with PFA
| Product Code: | IQ444 |
| Reactivity: | Mouse |
| Application: | Immunoblot, Immunofluorescence |
Lamin A+C Antibody [JOL2]
| Product Code: | IQ332 |
| Reactivity: | Human, African Green Monkey |
| Application: | Immunohistochemistry (paraffin sections), Western blot, Flow cytometry, Immunoprecipitation |
Lamin A Antibody [JOL4]
| Product Code: | IQ330 |
| Reactivity: | Human, Mouse |
| Application: | Immunofluorescence, Immunohistochemistry (frozen sections), Western blot, Immunoprecipitation |
Lamin A Antibody [JOL4]
Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
| Product Code: | IQ329 |
| Reactivity: | Human, Mouse |
| Application: | Immunofluorescence, Immunohistochemistry (frozen sections), Western blot, Immunoprecipitation |
Emerin Antibody
| Product Code: | IQ324 |
| Reactivity: | Mouse, Rat, Hamster |
| Application: | Immunoblot, Immunofluorescence |
Emerin Antibody
Immunocytochemistry/ Immunofluorescence - Anti-Emerin antibody at a 1/100 dilution
| Product Code: | IQ323 |
| Reactivity: | Mouse, Rat, Hamster, Human |
| Application: | Immunoblot, Immunofluorescence |
TAP1 Antibody [53H8]
| Product Code: | IQ279 |
| Reactivity: | Human |
| Application: | ELISA,Immunofluorescence,Western blot,Immunoprecipitation |
Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
| Product Code: | IQ252 |
| Reactivity: | Mouse, Human |
| Application: | Immunofluorescence, Western blot |
Lamin A+C Antibody [JoL3] - Nuclear Envelope Marker
Immunocytochemistry/ Immunofluorescence - Lamin A + C antibody [JoL3] - Nuclear Envelope Marker
| Product Code: | IQ251 |
| Reactivity: | Mouse, Rat, Human |
| Application: | Immunofluorescence, Western blot |
Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker
| Product Code: | IQ188 |
| Reactivity: | Mouse, Human |
| Application: | Immunofluorescence, Western blot |
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