Nuclear Envelope Antibodies

Nuclear envelope antibodies relate to the nuclear envelope which is a thin membrane that surrounds the genetic material in eukaryotic cells. It consists of a double layer of lipids, separating the nucleus content, principally DNA, from the surrounding cell cytoplasm.

The outer part of the nuclear envelope membrane is rough endoplasmic reticulum spotted as it is with ribosomes. The inner part consists of flat membrane proteins e.g. Emerin which are linked to the nuclear lamina and mutations in Lamins A and B

These mutations are thought to be linked to laminopathic diseases like Emery Dreifuss muscular dystrophy, limb-girdle muscular dystrophy type 1B, dilated cardiomyopathy with conduction defect, and Charcot-Marie-Tooth disorder type 2B1 which the use of nuclear envelope antibodies reach is indicated

The nuclear envelope is perforated with pores which enable the transport of proteins and RNA between the nucleus and cytoplasm. The inner and outer membrane conjoin at each nuclear pore site.

Nuclear envelope antibodies are available in various quantities including 0.05 ml, 0.1ml, 0.2 ml ,1 ml.

SUN2 Antibody

Product Code:IQ563
Reactivity: Mouse 
Application: WB, ICC/IF
Citation Count: 1
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TAP1 Antibody [53H8]

Product Code:IQ224
Reactivity: Human 
Application: ELISA, WB, IP, ICC/IF
Citation Count: 1
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Lamin A/C Antibody [JOL3]

Product Code:IQ251
Reactivity: Human, mouse & rat
Application: IF
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Nesprin 1 Monoclonal Antibody [MANNES1A(7A12)]

Product Code:IQ568
Reactivity: Mouse, Rat, Rabbit, Human
Application: ICC/IF, WB
Citation Count: 5
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Nesprin 2 Monoclonal Antibody [K20-478-5]

Product Code:IQ562
Reactivity: Human 
Application: ICC/IF, WB, IP, Electron Microscopy
Citation Count: 6
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Nesprin 2 Antibody

Product Code:IQ565
Reactivity: Mouse 
Application: WB, IP, ICC/IF
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Nesprin 3 Antibody

Product Code:IQ566
Reactivity: Mouse 
Application: WB, IP, ICC/IF
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Lamin A+C mutant R453W Antibody [12A-2F5]

Product Code:IQ541
Reactivity: Human
Application: WB, IP, ICC/IF
Citation Count: 1
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Lamin A+C Antibody [JOL2]

Product Code:IQ332
Reactivity: Human, African Green Monkey
Application: ICC/IF, IHC-Fr, IHC-P, WB, IP, Flow Cyt
Citation Count: 38
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Lamin A Antibody [JOL4]

Product Code:IQ330
Reactivity: Human, Mouse
Application: IF, IHC(Fr), IP, WB
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Emerin Antibody

Product Code:IQ324
Reactivity: Mouse, Rat, Hamster
Application: WB, ICC/IF, Electron Microscopy
Citation Count: 1
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Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Code:IQ252
Reactivity: Mouse, Human
Application: ICC/IF, WB
Citation Count: 3
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Lamin C Antibody

Product Code:IQ177
Reactivity: Human, Mouse, Rat 
Application: ICC/IF, IHC-P, IHC-Fr, WB, Flow Cyt
Citation Count: 5
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LAP2 alpha antibody

Product Code:IQ175
Reactivity: Mouse, Rat, Human
Application: ChIP, IP, ICC/IF, WB
Citation Count: 4
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