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Clustered regularly interspaced short palindromic repeat (CRISPR) and associated CRISP-R associated nuclease (Cas) proteins comprise the CRISPR/Cas systems responsible for adaptive immunity in many bacteria and archaea. Three types of CRISPR/Cas systems have been identified to date, designated t... View Post -
Muslimov et al. Abstract In neurons, regulation of gene expression occurs in part through translational control at the synapse. A fundamental requirement for such local control is the targeted delivery of select neuronal mRNAs and regulatory RNAs to distal dendritic sites. The nature of spatial... View Post
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Abstract The heart exhibits remarkable adaptive responses to a wide array of genetic and extrinsic factors to maintain contractile function. When compensatory responses are not sustainable, cardiac dysfunction occurs, leading to cardiomyopathy. The many forms of cardiomyopathy exhibit a set of o... View Post
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