DNA Damage Recognition Antibodies

DNA damage recognition antibodies are useful in understanding mechanisms related to DNA repair, sets of linked processes in which a cell interprets and actively trys to correct damage to the DNA molecules that encode the cell genome.

DNA damage recognition antibodies research help elucidate damage caused by stressors, environmental (eg UV light, radiation ) and metabolic (e.g. oxidative and alkylation) and a cells ability to repair in the face of what can be up to 1 million molecular cell lesions per day.

DNA damage is implicated in wide range of disease areas including cancer and tumour formation.

DNA damage recognition antibodies are available in the following volumes 0.05 ml, 0.1 ml, 0.2 ml, 0.5 ml, 1ml and 2 ml

Research Notes on DNA damage recognition antibodies are available

RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody [4H8] - ChIP Grade

Product Code:IQ585
Reactivity: Mouse, Human, Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, Fruit fly (Drosophila melanogaster), Schizosaccharomyces pombe, African Green Monkey
Application: Immunoblot, Immunofluorescence, Immunocytochemistry, Western blot, Flow cytometry, Immunoprecipitation
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RNA polymerase II CTD repeat YSPTSPS (phospho S5) Antibody [8A7]

Product Code:IQ586
Reactivity: Human, Saccharomyces cerevisiae. Predicted to work with: Mouse, Hamster, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), Schizosaccharomyces pombe
Application: Immunofluorescence, Western blot, Flow cytometry, Immunoprecipitation
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BRIT1 Antibody [AB11]

immunofluorescence image showing COS cells stained with BRIT1 Antibody [AB11] expressing GFP microcephalin

Product Code:IQ539
Reactivity: Human
Application: ELISA, Immunofluorescence, Western blot, Immunoprecipitation
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PARP2 Antibody

Western blot - PARP2 antibody

Product Code:IQ547
Reactivity: Human 
Application: ELISA, Immunoblot, Western blot
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ORC1 Antibody [7A7]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins The protein encoded by this gene is the largest subunit of the ORC complex While other ORC subunits are stable throughout the cell cycle the levels of this protein vary during the cell cycle which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication This protein is found to be selectively phosphorylated during mitosis It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1) a protein involved in control of transcription silencing

Product Code:IQ309
Reactivity: Human 
Application: Western blot, Immunoprecipitation
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ORC3L Antibody [1D6]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC3 is a subunit of the ORC complex Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory

Product Code:IQ308
Reactivity: Human 
Application: Western blot, Immunoprecipitation
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ORC2 Antibody [3G6]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC2L is a subunit of the ORC complex ORC2L forms a core complex with ORC3L 4L and 5L It also interacts with CDC45L and MCM10 which are proteins known to be important for the initiation of DNA replication ORC2L specifically associate with the origin of replication of Epstein Barr virus in human cells and is thought to be required for DNA replication from viral origin of replication

Product Code:IQ307
Reactivity: Human 
Application: Western blot, Immunoprecipitation
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ORC6L Antibody [3A4] - ChIP Grade

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins ORC6L is a subunit of the ORC complex It has been shown that ORC6L and and ORC1L are loosely associated with the core complex consisting of ORC2L 3L 4L and 5L Gene silencing studies with small interfering RNA demonstrated that ORC6L plays an essential role in coordinating chromosome replication and segregation with cytokinesis

Product Code:IQ306
Reactivity: Human
Application: Western blot, Immunoprecipitation
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RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody [8A7]

Immunocytochemistry/ Immunofluorescence - RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody [8A7] in Human HeLa cells

Product Code:IQ295
Reactivity: Human, Saccharomyces cerevisiae. Predicted to work with: Mouse, Hamster, Arabidopsis thaliana, Fruit fly (Drosophila melanogaster), Schizosaccharomyces pombeImmunogen
Application: ELISA, Immunofluorescence, Western blot, Flow cytometry
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RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody [4H8] - ChIP Grade

Immunofluorescence - RNA polymerase II CTD repeat YSPTSPS antibody [4H8] in HeLa or MCF7 cells

Product Code:IQ287
Reactivity: Mouse, Human, Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, Fruit fly (Drosophila melanogaster), Schizosaccharomyces pombe, African Green Monkey
Application: ELISA, Immunofluorescence, Immunocytochemistry, Western blot, Flow cytometry, Immunoprecipitation
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Eme1 Antibody [7h2/1]

EME1 complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein (MUS81) to form an endonuclease complex which cleaves branched DNA structures, especially those arising during stalled DNA replication. The protein may be involved in repairing DNA damage and in maintaining genomic stability. It interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Alternative splicing results in multiple transcript variants.

Product Code:IQ284
Reactivity: Human 
Application: Western blot
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