Nuclear Transport Antibodies

Nuclear transport antibodies relate to the large molecules are carried bi-directionally across the nuclear envelope by a RAN (ras-related nuclear protein) GTP nuclear transport cycle.

Nuclear transport processes RNA and proteins are enabled to enter the nucleus via specialist karyopherin proteins importins and facilitated outbound by exportins via the nuclear pore structures e.g. Transportin1 . Both exportins and importins abilities are regulated by GTPase.

Nuclear transport antibodies are useful in understanding the direction of the nuclear transport cycle is triggered by localisation signals in an active process that can be negatively affected in human neurodegenerative diseases like Parkinsons and suggest nuclear protein import directly participate in the pathogenesis of diseases such as hypertension, atherosclerosis, cancer, viral infection, and diabetes.

Nuclear transport antibodies are available in the following various quantities including 0.05 ml, 0.1ml, 0.2 ml, 1 ml

Lamin A+C Antibody [JOL2]: Horseradish peroxidase

IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon

Product Code:IQ608HRP
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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Lamin A+C Antibody [JOL2]

Product Code:IQ608
Reactivity: Human, African Green Monkey
Application: Immunoblot, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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Emerin Antibody

Product Code:IQ324
Reactivity: Mouse, Rat, Hamster
Application: Immunoblot, Immunofluorescence
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KPNA2 Antibody [2G7]

The import of proteins into the nucleus is a process that involves at least 2 steps The first is an energy independent docking of the protein to the nuclear envelope and the second is an energy dependent translocation through the nuclear pore complex Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart Proteins involved in the first step of nuclear import have been identified in different systems These include the Xenopus protein importin and its yeast homolog SRP1 (a suppressor of certain temperature sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae) which bind to the NLS KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins KPNA2 also may play a role in V(D)J recombination

Product Code:IQ305
Reactivity: Mouse, Human. Predicted to work with Rat 
Application: Western blot
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RCC1 Antibody

Immunohistochemistry of RCC1 on formalin fixed paraffin embedded skin tissue at 1:100

Product Code:IQ247
Reactivity: Human, Xenopus laevis
Application: Immunofluorescence, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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RanGAP1 Antibody

Immunohistochemistry showing RanGAP on formalin fixed paraffin embedded skin tissue at 1:100

Product Code:IQ246
Reactivity: Mouse, Human, Xenopus laevis
Application: Immunofluorescence, Immunohistochemistry (paraffin sections), Western blot
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Ran Antibody

Product Code:IQ245
Reactivity: Human, Xenopus laevis
Application: Immunofluorescence, Western blot, Immunoprecipitation
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TAP1 Antibody [53H8]

Western blot - TAP1 antibody [53H8]

Product Code:IQ224
Reactivity: Human 
Application: ELISA, Immunofluorescence, Western blot, Immunoprecipitation
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Transportin 1 Antibody [D45]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Transportin 1 antibody [D45]

Product Code:IQ223
Reactivity: Mouse, Rabbit, Human, Monkey
Application: ELISA, Immunofluorescence, Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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