Nuclear transport antibodies relate to the large molecules are carried bi-directionally across the nuclear envelope by a RAN (ras-related nuclear protein) GTP nuclear transport cycle.
Nuclear transport processes RNA and proteins are enabled to enter the nucleus via specialist karyopherin proteins importins and facilitated outbound by exportins via the nuclear pore structures e.g. Transportin1 . Both exportins and importins abilities are regulated by GTPase.
Nuclear transport antibodies are useful in understanding the direction of the nuclear transport cycle is triggered by localisation signals in an active process that can be negatively affected in human neurodegenerative diseases like Parkinsons and suggest nuclear protein import directly participate in the pathogenesis of diseases such as hypertension, atherosclerosis, cancer, viral infection, and diabetes.
Nuclear transport antibodies are available in the following various quantities including 0.05 ml, 0.1ml, 0.2 ml, 1 ml