Cell Cycle Antibodies

Cell Cycle Antibodies for research into the Cell Cycle which has four distinct phases, G1, S, G2 and M collectively representing cell division which follows a highly regulated pathway culminating in mitosis in eukaryotes.

Cell cycle antibody research into disruption of the cell cycle has been implicated in tumour formation and growth, active cell division targeting in treating cancer and negative cardiovascular incidents.

Cell cycle antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.

hCAP-D3 Antibody [2B5]

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4. hCAP-D3 is a regulatory non-SMC subunit of the condensin II complex

Product Code:IQ554
Reactivity: Human 
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HDAC3 Antibody [3G6]

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation

Product Code:IQ553
Reactivity: Human, Mouse 
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HDAC1 Antibody [10E2]

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity

Product Code:IQ555
Reactivity: Mouse, Rat, Human
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