Checkpoint Control Antibodies

Checkpoint control antibodies that helps to understand the regulatory pathways of the cell cycle via a series of checkpoints which are coterminous with each part of the well established cell cycle mechanisms.

Check point control antibodies are utilized in research in understanding the cell phasing pathways and the prevention of DNA damage across the cell cycle.

Checkpoint control antibodies are implicated in genetic instability birth defects and cancer biology.

Checkpoint control antibodies are available in the following volumes including 0.05 ml, 0.1ml, 0.2 ml, 1 ml and 2 ml.

Bub1 Antibody [14H5]

Product Code:IQ255
Reactivity: Mouse, Human. Predicted to work with: Rat, Xenopus laevis, Kangaroo
Application: Immunofluorescence,Western blot,Immunoprecipitation
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CENPE Antibody [1H12]

Product Code:IQ254
Reactivity: Human 
Application: Immunoblot,Immunofluorescence,Immunocytochemistry,Western blot,Immunoprecipitation
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Mad1 Antibody [9B10]

Product Code:IQ253
Reactivity: Human 
Application: Immunofluorescence,Immunoprecipitation
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Mad2 Antibody

MAD2 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators.hMAD2 is the human homologue of yeast MAD2

Product Code:IQ243
Reactivity: Human, Saccharomyces cerevisiae
Application: Immunofluorescence, Western blot
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Mad1 Antibody

MAD1 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of anaphase in cells with defects in mitotic spindle assembly or in the attachment of chromosomes to the spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated upon spindle depolymerization

Product Code:IQ242
Reactivity: Saccharomyces cerevisiae
Application: Immunofluorescence, Western blot
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Mad2L1 Antibody [17D10]

Colon cancer fixed with formalin (after antigen retreival) and stained with Mad2L1 antibody, clone 17D10

Product Code:IQ239
Reactivity: Human
Application: Immunohistochemistry (paraffin sections), Western blot, Immunoprecipitation
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CENPE Antibody [1H12]

Ovarian cancer cells were arrested with Nocodazole before fixation; primary Ab: anti-CenpE mAb (clone 1H12); Secondary Ab: anti-mouse Alexa 488; chromosome visualization: DAPI

Product Code:IQ201
Reactivity: Human 
Application: Immunoblot,Immunocytochemistry,Western blot,Immunoprecipitation
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Bub1 Antibody [14H5]

Ovarian cancer cells were arrested with Nocodazole before fixation; primary Ab: anti-Bub1 mAb (clone 14H5); Secondary Ab: anti-mouse Alexa 488; chromosome visualization: DAPI

Product Code:IQ198
Reactivity: Mouse, Human. Predicted to work with: Rat, Xenopus laevis, Kangaroo
Application: Immunofluorescence, Western blot, Immunoprecipitation
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