CRISPR/Cas9 Antibodies

Cas9 is an RNA guided DNA nuclease associated with the type II CRISPR/Cas adaptive immune systems.  In prokaryotes, the CRISPR/Cas9 system protects the viruses and plasmids by targeting foreign nucleic acids and with complementary single-stranded RNA.  This localizes the Cas9 nuclease to the target DNA sequence, introducing double-strand breaks at specific locations with the genomic DNA.

The CRISPR/Cas9 system has the potential to transform developmental biology by providing a simple, efficient method to precisely manipulate the genome of virtually any developing organism.