Lamin Antibodies

The group of Lamin antibodies (A,B and C) make up a large proportion of the cell structure of the nuclear lamina. This group of antibodies have been extensively used in research in the area of Ageing. Immuquest has a unique range of Lamins and are the EXCLUSIVE manufacturer of the well researched, and validated clone JOL2.

You can read more about our Lamin Antibodies in this blog post.

Lamin A Antibody [JOL4]: FITC

Product Code:IQ657FITC
Reactivity: Human
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Lamin A Antibody [JOL4]: HRP

Product Code:IQ657HRP
Reactivity: hUMAN
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Lamin A Antibody [JOL4]

Product Code:IQ657
Reactivity: Human
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Lamin A/C Antibody [JOL3]: HRP

Product Code:IQ656HRP
Reactivity: Human, mouse & rat
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Lamin A/C Antibody [JOL3]

Product Code:IQ656
Reactivity: Human, mouse & rat
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Lamin A/C Antibody [JOL2]: Biotin

Product Code:IQ608B
Reactivity: Human
Application: Immunoprecipitation, western blot, flow cytometry & immunohistology
Citation Count: 2
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Lamin A/C antibody [JOL3]: FITC

Confocal optical section, green is FITC (lamin A/C [JOL3]) and blue is DAPI (DNA). Cells were fixed in 4% paraformaldehyde in PEM buffer then extracted with 0.5% Triton X-100 before labelling with JOL3-FITC.

Product Code:IQ656FITC
Reactivity: Human, Mouse, Rat
Application: Immunofluorescence,Immunocytochemistry
Citation Count: 1
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Lamin A+C Antibody [JOL2]: Horseradish peroxidase

IHC using Lamin A+C Antibody [JOL2]: HRP conjugate on fixed human colon

Product Code:IQ608HRP
Reactivity: Human, African Green Monkey
Application: Immunoblot,Immunohistochemistry (paraffin sections),Western blot,Immunoprecipitation
Citation Count: 1
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Lamin A+C Antibody [JOL2]

Product Code:IQ608
Reactivity: Human, African Green Monkey
Application: Immunoblot,Immunohistochemistry (paraffin sections),Western blot,Immunoprecipitation
Citation Count: 4
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Lamin A+C mutant R482W Antibody [5H8-B4]

Lamins and lamin-associated proteins help cell nuclear shape to remain appropriate and also provide a scaffold-type support system for chromosomes and replicating DNA to interact with epigenetic machinery. When mutations to these important proteins occur, serious familial diseases are instigated. The R482W lamin mutation causes familial partial lipodystrophy (FPLD) phenotypes, a disorder that causes affected individuals to be incapable of normal fat distribution, to have insulin resistance, dyslipidemia and early cardiac heart disease. The mutation affects the lamin C-terminal domain's ability to bind DNA, and is typically thought to be attributed to oxidative stress. Women affected by FPLD are even more afflicted, in that they are at a higher risk of infertility, gestational diabetes, obstectrical complications, insulin regulation dysfunctions, and hypercholesterolemia

Product Code:IQ546
Reactivity: Human
Citation Count: 1
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Lamin A+C mutant R453W Antibody [12A-2F5]

Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamin A and Lamin C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R453W mutation is one of the most common causes of autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD)

Product Code:IQ541
Reactivity: Human
Citation Count: 1
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Lamin A+C Antibody [JOL2]

Product Code:IQ332
Reactivity: Human, African Green Monkey
Application: Immunohistochemistry (paraffin sections),Western blot,Flow cytometry,Immunoprecipitation
Citation Count: 38
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Lamin A Antibody [JOL4]

Product Code:IQ330
Reactivity: Human, Mouse
Application: Immunofluorescence, Immunohistochemistry (frozen sections), Western blot, Immunoprecipitation
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Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Code:IQ252
Reactivity: Mouse, Human
Application: Immunofluorescence, Western blot
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Lamin A+C Antibody [JoL3] - Nuclear Envelope Marker

Immunocytochemistry/ Immunofluorescence - Lamin A + C antibody [JoL3] - Nuclear Envelope Marker

Product Code:IQ251
Reactivity: Mouse, Rat, Human
Application: Immunofluorescence, Western blot
Citation Count: 2
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Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Western blot - Lamin A + C antibody [JoL5] - Nuclear Envelope Marker

Product Code:IQ188
Reactivity: Mouse, Human
Application: Immunofluorescence,Western blot
Citation Count: 2
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